Seminar CeNT 15.11.2019
12 listopada 2019The Centre of New Technologies invites to a seminar by
prof. Marek Cieplak
Head of Laboratory of Biological Physics, Institute of Physics, Polish Academy of Sciences
Title: „Interbasin traffic and emergence of knots in intrinsically disordered proteins”
Date: November 15th, 2019 at 12 p.m.
Venue: Centre of New Technologies, Banacha 2C,
Lecture Hall 0142 (Ground floor)
Host: prof. Joanna Trylska and prof. Dariusz Plewczyński
Abstract:
The equilibrium dynamics of the intrinsically disordered proteins is thought to consist of transitions between many basins in the free energy landscape whereas structured proteins stay in the vicinity of one native basin. We demonstrate this picture explicitly by studying networks defined on the discretized plane: conformational end-to-end distances vs. radii of gyration. The bin sizes are defined by time scales that span orders of magnitude. The networks, derived from all-atom and coarse-grained molecular dynamics simulations, are nearly scale invariant. The bin representation also provides insights into the folding proces of the structured proteins and identifies regions of hindrance to folding. Transient knotted structures are expected to arise during the volatile evolution of intrinsically disordered peptide chains. We show that this is indeed the case for sufficiently long polyglutamine tracts and α-synuclein. The polyglutamine tracts are fused within huntingtin protein that is associated with the Huntington neurodegenerative disease. We show that the presence of knots in the tracts hinders and sometimes even jams translocation, especially when the knots are deep. The knots in polyglutamine may form in tracts exceeding about 40 residues. This fact explains the existence of a similarly sized length treshold above which there is an experimentally observed toxicity at the monomeric level. We also discuss emergence of knots in α-synuclein. We show that these knots are either shallow or deep and last for about 3 – 5 µs, as inferred from an all-atom explicit-solvent 20 and 30 µs trajectories. We discuss conformational biasses that take place in α-synuclein and contact formation during association of two chains of this protein.
In collaboration with: M. Chwastyk, Ł. Mioduszewski, B. de Aquino, A. Gomez-Sicilia, M. Carrion-Vazquez, P. Robustelli.
Seminar CeNT 25.09.2019
23 września 2019The Centre of New Technologies invites to a seminar by
Dr. Sarah Knowles
Research Fellow at the Department of Zoology, University of Oxford,
United Kingdom
What makes a microbiome? Ecological and evolutionary forces shaping the gut microbiota in wild mammals
Date: September, 25th (Wednesday), 2019 at 12 p.m.
Venue: Centre of New Technologies, Banacha 2C,
Lecture Hall 0142 (Ground floor)
Host: Prof. Marta Szulkin
Please see the attachment for more details.
Seminar CeNT 17.07.2019
16 lipca 2019The Centre of New Technologies invites to a seminar by
Dima Kozakov, PhD
Stony Brook University, Department of Applied Mathematics and Statistics
Efficient sampling and optimization on manifolds for macromolecular docking
Date: July, 17th (Wednesday), 2019 at 12.30 p.m.
Venue: Centre of New Technologies, Banacha 2C,
Lecture Hall 0142 (Ground floor)
Host: dr. hab Joanna Sułkowska
Please see the attachment for more details.
Seminar CeNT 15.07.2019
08 lipca 2019The Centre of New Technologies invites to a seminar by
Jung-Shin Lee Ph.D.
Department of Molecular Bioscience, College of Biomedical Sciences, Kangwon National University, Kangwondaehak-gil, Chuncheon-si, Gangwon-do, 24341 Republic of Korea
Transcriptional regulation by methylation of the fourth lysine on histone H3 in yeasts
Date: July, 15th (Monday), 2019 at 12 p.m.
Venue: Centre of New Technologies, Banacha 2C,
Lecture Hall 0142 (Ground floor)
Host: Prof. Magda Konarska
For more details, please see the attachment.
Seminar CeNT 28.06.2019
24 czerwca 2019The Centre of New Technologies invites to a seminar by
Prof. Alfredo Ferro
Department of Clinical and Experimental Medicine, University of Catania
Computational pathway analysis and simulation in cancer
Date: June, 28th (Friday), 2019 at 12 p.m.
Venue: Centre of New Technologies, Banacha 2C,
Lecture Hall 0142 (Ground floor)
Host: Dr. Marta Dudek
For more details, please see the attachment.
Seminar CeNT 7.06.2019
03 czerwca 2019ReMedy International Research Agenda invites to a special lecture:
„Liquid-type condensates in transcription and RNA splicing”
by
Prof. Phillip A. Sharp
Institute Professor and Professor of Biology, Member,
Koch Institute for Integrative Cancer Research,
Massachusetts Institute of Technology, Cambridge, MA
June 7th, 2019, 12:00 pm
CeNT UW, Banacha 2C, Lecture Hall 0142
Host: Magda Konarska
Seminar CeNT 31.05.2019
28 maja 2019The Centre of New Technologies invites to a seminar by
Prof. Stefan Dziembowski
Faculty of Mathematics, Informatics and Mechanics, University of Warsaw
Crypto in Crypto
Date: May, 31st (Friday), 2019 at 12 p.m.
Venue: Centre of New Technologies, Banacha 2C,
Lecture Hall 0142 (Ground floor)
Host: Prof. Marta B. Wiśniewska
For more details, please see the attachment.
Seminar CeNT 1.03.2019
26 lutego 2019The Centre of New Technologies invites to a seminar by
Dawid Walerych, PhD
How mutant p53 and the proteasome machinery reshape transcriptomes and proteomes of cancer cells
Date: March 1st, 2019 at 12 p.m.
Venue: Centre of New Technologies, Banacha 2C,
Lecture Hall 0142 (Ground floor)
Host: Marta B. Wiśniewska
For more details please see the attachment.
Seminar CeNT 22.02.2019
18 lutego 2019The Centre of New Technologies invites to a seminar by
Dr. Sebastian Glatt
Malopolska Centre of Biotechnology (MCB), Jagiellonian University
Charging the Code – Insights into tRNA Modification Enzymes
Date: February, 22nd (Friday), 2019 at 12 p.m.
Venue: Centre of New Technologies, Banacha 2C,
Lecture Hall 0142 (Ground floor)
Host: Prof. Agnieszka Chacińska
For more details, please see the attachment.
Seminar CeNT 25.01.2019
22 stycznia 2019The Centre of New Technologies of the University of Warsaw
invites to a seminar by
Prof. Gianluca Tell
University of Udine
„Non canonical roles of BER enzymes in RNA processing: novel perspectives in cancer biology through the study of APE1 protein – and RNA –interactomes. ”
January, 25th (Friday), 2019 at 12 p.m.
Venue: Centre of New Technologies, Banacha 2C
Lecture Hall 0.142 (Ground floor)
Host: Dr. Carlo Vascotto
For more details, please see the attachment.