Title: NON-CODING RNA: FROM DARK MATTER TO THE REAL DEAL

Date: 5 th November 2021, Friday

Time: 1:00 pm (Central European Summer Time)

Host: Jeff Palatini, PhD

Zoom link: https://us02web.zoom.us/j/82426581314

Seminars can also be watched in the Auditorium (room 0142).

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Abstract:

The presentation will cover several aspects of the non-coding RNA – a vast amount of RNA that does not encode for proteins, yet is produced at high cost by all our cells, often in cell-, tissue-, and physiopathological condition-specific manner, suggestive of an intricate regulatory network. Scientists in the bio-medical field tended to overlook the importance of non-coding RNA, often missing their critical chance in discovering therapeutic targets and developing therapeutic agents. This talk will present the evolution of our understanding of the role and importance of non-coding RNA from „dark matter” or even „junk” to bonafide biomarkers and therapeutic targets in various pathologies. The talk will give participants overlook of the complexity of the universe of non-coding RNAs, their classification, role, and impact, providing a new layer in our understanding of physiopathology. Using deadly brain tumor – glioblastoma as a model (the author will disclose basic details on disease’s key aspects), and several noteworthy examples generated by over 15 years of research by the author’s group, the participants will be presented various aspects of the pathobiology of several key players in non-coding RNA world: microRNAs, long non-coding RNAs, and circular RNAs. These aspects will include disease-related (causal vs. causative) changes in their prevalence, their molecular and phenotypic footprint (with only superficial scrutiny of their mechanistic roles), and finally, their usefulness as either therapeutic targets or therapeutic agents in the development of experimental pre-clinical therapeutic avenues against glioblastoma.

IDUB training courses in cooperation with the Springer Nature

UW employees and doctoral candidates can take part in the latest online training courses, as part of the following “Excellence Initiative – Research University” (IDUB) in cooperation with the Springer Nature publishing house. Registrations for the course “Journal Editors” close on 5th November.

Springer Nature is one of the world’s largest publishers of scientific journals (over 3,000 titles, containing over seven million scientific papers). Among the journals published by SN, more than 1,100 journals may be found in the top quartile in the Scopus database; the company publishes many of the most influential journals in the world.

These workshops are part of the following “Excellence Initiative – Research University’ (IDUB) Actions: I.2.1 – “Improvement of publishing capacities”, V.3.1 – “Development of UW staff competences”, and V.3.5 – “Programme for the development and improvement of the researchers’ soft skills”.

The following training courses will take place by the end of 2021:

“Journal Editors”: 16th-17th November; registrations close on 5th November;
“Academic Presentations”: 29th-30th November; registrations close on 21st November;
“Science Communication”: 1st-2nd December; registrations begin on 2nd November until 23rd November;
“Getting Published”: 3rd, 13th and 17th December; registrations begin on 2nd November until 25th November.

See the full schedule >>

The training courses are open to:

“Journal Editors” – representatives of the editorial boards from the scientific journals which are affiliated with the University of Warsaw;
other training courses – academic teachers (mainly those employed as research and teaching staff and research staff), and administrative staff who are employed under an employment contract or other appointment at the University of Warsaw, throughout the duration of the training period, and young researchers (doctoral candidates).

Training courses are conducted in English, in the form of workshops.

Registrations are carried out on the Kampus Pracownik platform, in the category of courses called “Inicjatywa Doskonałości – Uczelnia Badawcza (IDUB)” (“Excellence Initiative – Research University (IDUB)”) on the dates indicated: https://kampus-pracownik.ckc.uw.edu.pl. Detailed information and the programme can be found in the description of the courses on the platform.

The training courses are being organised as part of the development activities foreseen in the IDUB programme. A full list of developmental activities is available at: www.inicjatywadoskonalosci.uw.edu.pl/rozwoj/.

Source: www.en.uw.edu.pl